Our Research Focus: Understanding molecular mechanisms controlling inflammatory response
- Sensing and signaling in innate immunity (TLRs, Inflammasomes, cGAS/STING)
- Autoinflammatory diseases (e.g., SAVI - STING associated Vasculopathy with onset in Infancy)
- Therapeutic targeting of Inflammasomes and cGAS/STING Signaling
Representative Publications
- Chen Y, Lei X, Jiang Z, Fitzgerald KA. Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2100383118.
- Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells. Immunity. 2021 Jun 8;54(6):1137-1153.e8.
- Motwani M, McGowan J, Antonovitch J, Gao KM, Jiang Z, Sharma S, Baltus GA, Nickerson KM, Marshak-Rothstein A, Fitzgerald KA. cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE. Front Immunol. 2021 Mar 29;12:605930.