Lab Members
 |
Neil Aronin, MD (PI) |
 |
Kathryn Chase (Lab Manager, Senior Research Scientist) Research Projects: In vivo modifiers of HD pathology. Safety and immune responses following long-term administration of siRNAs and artificial miRNAs in the mammalian brain. |
 |
Lori Kennington (Research Associate) Research Projects: RNAi in cell culture and mouse models of HD. Alternative strategies for allele specific silencing of mutant huntingtin. |
 |
Edith Pfister (Project Manager, Postdoctoral Associate) Research Projects: Development and optimization of RNAs to silence human huntingtin, Allele-specific targeting of human huntingtin. Delivery and processing of small RNAs in the mammalian brain. |
 |
Erica Mondo (Research Technician) Research Projects: Spread, safety, and neuronal uptake of different serotypes of AAV in sheep brain. |
 |
Lauren Hall (Research Technician) Research Projects: Purification and characterization of exosomes for siRNA delivery and KD of huntingtin. Quantification of human htt expression using qPCR for ROS experiments in primary neurons. |
 |
Emily Sottosanti (Research Technician) Research Projects: In vivo bioluminescent screening of RNAi silencing in the mammalian brain. |
 |
Emily Johnson (Research Technician) Research Projects: Immune response to siRNA/miRNA in the brain. Regulated expression of artificial miRNAs. |
 |
Wanzhao Liu, Ph.D. (Instructor) Research Projects: Steady-state levels of mutant and normal Huntingtin mRNA in HD patients. |
 |
Lindsay Romo (MD/PhD Candidate) Research Projects: Characterization of microRNA profiles in Huntington’s mouse models and human Huntington’s brains. Identification and confirmation of allele-specific microRNA targeting of Huntingtin. Development of microRNA vectors to target mutant Huntingtin. |