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Selected Recent Publications of Michael A. Brehm, PhD

A complete list of published work can be found in My Bibliography

Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

Leite NC, Sintov E, Meissner TB, Brehm MA, Greiner DL, Harlan DM, Melton DA.
Cell Rep. 2020 Jul 14;32(2):107894. doi: 10.1016/j.celrep.2020.107894.PMID: 32668238

Humanized immune system mouse models: progress, challenges and opportunities

Allen TM, Brehm MA, Bridges S, Ferguson S, Kumar P, Mirochnitchenko O, Palucka K, Pelanda R, Sanders-Beer B, Shultz LD, Su L, PrabhuDas M.
Nat Immunol. 2019 Jul;20(7):770-774. doi: 10.1038/s41590-019-0416-z. No abstract available. PMID: 31160798

Humanized mouse models of immunological diseases and precision medicine

Shultz LD, Keck J, Burzenski L, Jangalwe S, Vaidya S, Greiner DL, Brehm MA.
Mamm Genome. 2019 Jun;30(5-6):123-142. doi: 10.1007/s00335-019-09796-2. Epub 2019 Mar 7. Review. PMID: 30847553

Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim

Jangalwe S, Kapoor VN, Xu J, Girnius N, Kennedy NJ, Edwards YJK, Welsh RM, Davis RJ, Brehm MA.
J Immunol. 2019 Feb 1;202(3):647-651. doi: 10.4049/jimmunol.1800278. Epub 2019 Jan 4. PMID: 30610162

Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression

Brehm MA, Kenney LL, Wiles MV, Low BE, Tisch RM, Burzenski L, Mueller C, Greiner DL, Shultz LD.
FASEB J. 2019 Mar;33(3):3137-3151. doi: 10.1096/fj.201800636R. Epub 2018 Nov 1. PMID: 30383447

Survival advantage of both human hepatocyte xenografts and genome edited hepatocytes for treatment of alpha-1 antitrypsin deficiency

Borel, F., Q. Tang, G. Gernoux, C. Greer, Z. Wang, A. Barzel, M..A. Kay, L.D. Shultz, D.L. Greiner, T.R. Flotte, M.A. Brehm, and C. Mueller.
Molecular Therapy, 25:2477-2489, 2017.

Alloimmune responses of humanized mice to human pluripotent stem cell therapeutics

Kooreman, N.G., P.E. de Almeida, J.P. Stack, R.V. Nelakanti, S. Diecke, N.Y. Shao, R.J. Swijnenburg, V. Sanchez-Freire, E. Matsa, C. Liu, A.J. Connolly, J.F. Hamming, P.H.A. Quax, M.A. Brehm, D.L. Greiner, L.D. Shultz, and J.C. Wu.
Cell Reports 20:1978-1990, 2017.