Our Research Focus: Innate immune recognition and signal transduction in flies and mammals

• How bacteria, viruses and parasites are recognized by innate immune receptors
• Molecular and biochemical mechanisms used by both the host and microbe to respond to infection
• The role of peptidoglycan sensing in inflammatory responses and diseases

Latest News from our Lab

Representative Publications

• Okuda K, Silva Costa Franco M, Yasunaga A, Gazzinelli R, Rabinovitch M, Cherry S, Silverman N. Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival. bioRxiv 2021.11.03.467107; doi: https://doi.org/10.1101/2021.11.03.467107

• ​Paik D, Monahan A, Caffrey DR, Elling R, Goldman WE, Silverman N. SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans. J Immunol. 2017 Jul 1;199(1):263-270.
  
  
• Kleino A, Ramia NF, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H, Li J, Silverman N. Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling. Immunity. 2017 Oct 17;47(4):635-647.e6.
  
  
  

More Publications

Join our Lab

We are currently recruiting for a post-doctoral position in our lab. Please contact Dr. Silverman directly if you are interested.