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Welcome

Our lab is interested in the mechanisms that control cell growth and proliferation, and in understanding how these pathways are disrupted in cancer cells. We study how transcription, phosphorylation and protein degradation contribute to the regulatory network that controls the eukaryotic cell cycle. 

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News & Events

June 2022: Our paper describing how Cip1 tunes the duration of stress-induced cell cycle arrest is published in PNAS
September 2021:
Our paper describing a role for Ubc1 turnover in the spindle checkpoint is published in G3
April 2020:
Our paper about how calcineurin and Hog1 rewire the cell cycle is published in PLoS Genetics
September 2019:
Mackenzie is awarded the Zelda Haidak Scholarship in Cell Biology. Congrats Mackenzie!
May 2019:
An order-to-disorder structural switch activates the FoxM1 transcription factor published in eLife
April 2019:
Mackenzie passes her qualifying exam. Congrats Mackenzie!
November 2018:
Claudine defends her disseration. Congrats Claudine!
September 2018:
A balance of deubiquitinating enzymes controls cell cycle entry published in Molecular Biology of the Cell
May 2018:
Michelle passes her qualifying exam. Congrats Michelle!

August 2016: Tyler Doughty defends his dissertation. Congrats Tyler!
July 2016: Levels of Ycg1 limit condensin function during the cell cycle published in PLoS Genetics
November 2015: Our Hcm1 paper is highlighted in the ASCB newsletter
November 2015: Create, activate, destroy, repeat: Cdk1 controls proliferation by limiting transcription factor activity review article published in Current Genetics
August 2015: Hcm1 integrates signals from Cdk1 and calcineurin to control cell proliferation published in Molecular Biology of the Cell


Our Affiliations

UMass Cancer Center